Highlight

Systematic and Matched Datasets

  • Well-defined donor：All data originate from 8 genetically and phenotypically characterized pigs.
  • Parallel multi-omics generation：Each of the 94 biological samples was systematically profiled across all omics layers, resulting in 1,172 experimental datasets (plus 82 imputation).
  • Unified Protocol & Pipeline

Comprehensive Spatiotemporal Coverage

  • Temporal Dimension: Covers 4 major developmental stages.
  • Spatial Dimension: Encompasses 11 major organs and 3 widely utilized cell lines.

Multi-Omics and 3D Genome Structure

  • Genome: Detection of SNPs, InDels, and structural variants.
  • Epigenome: Profiling of DNA methylation, chromatin accessibility, 7 histone modifications, 2 transcription factor binding.
  • 3D genome: Systematic identification of higher-order chromatin structures including A/B compartments, TADs, and loops
  • Transcriptome
  • Single-cell omics: scRNA-seq profiling of 3 major donor organs.

Functional Annotation of the Genome

  • Cis-regulatory elements (CREs): Identification of 1,067,540 CREs, bringing to the level of model organisms.
  • Element–gene interactions: Mapping proximal/distal element and gene regulatory connections.

Reference Atlas

  • Pig biology: Agricultural breeding, developmental dynamics, and evolutionary/domestication studies.
  • Xenotransplantation: Genome engineering modification.
  • Biomedical models: Cross-species conservation, gene-edited disease models.

Tissue Library

  • P21
  • P50
  • P100
  • P180
  • Adipose
  • Brain
  • Heart
  • Kidney
  • LInt
  • Liver
  • Lung
  • Muscle
  • SInt
  • Spleen
  • Testis
  • PK15 & ST & PIEC