Pig Matrix provides a systematically generated 3D regulatory reference for the pig by integrating matched multi-omics datasets across tissues, developmental stages, and porcine cell lines. Compared with resources derived mainly from heterogeneous public-data integration or linear regulatory annotation, Pig Matrix emphasizes standardized data generation and processing, matched sample design, and 3D genome-based assignment of candidate proximal and distal regulatory relationships. By connecting genome sequence, epigenomic state, chromatin architecture, and gene regulation within the same framework, Pig Matrix extends pig functional annotation beyond descriptive multi-omics collection toward a more interpretable platform for evolutionary and comparative analysis.

Looking ahead, we will continue to develop Pig Matrix as an evolving resource for pig regulatory genomics, comparative biology, and animal-model research. A major priority will be to expand its spatiotemporal coverage by incorporating additional tissues, developmental stages, pig populations, and future data releases, with particular emphasis on embryonic and fetal stages that are likely to be critical for developmental regulation and model-related phenotypes. We also plan to integrate emerging modalities, including single-cell chromatin accessibility and single-cell 3D genome data, to improve regulatory resolution across cell types and developmental trajectories. In parallel, we will continue updating the evolutionary, comparative, and xenotransplantation-related modules as new datasets, regulatory correspondences, and donor-engineering evidence become available. Because Pig Matrix is built on a matched and extensible framework, we expect it to remain a living resource that can support not only functional interpretation of pig genomes, but also long-term applications in comparative biology, translational modeling, and regulatory genomics.