Chromatin Compartments (Compartment)
Chromatin Compartments represent the macroscopic spatial partitioning of the genome within the nucleus. Contact matrices derived from high-throughput chromatin conformation capture assays exhibit characteristic plaid-like interaction patterns, reflecting the physical segregation and functional differentiation of chromatin. Through eigenvector decomposition, the genome can be categorized into two primary compartment types: A Compartment, corresponding to gene-rich, transcriptionally active, open chromatin regions typically located toward the nuclear interior; and B Compartment, associated with gene-poor, transcriptionally repressed, heterochromatic regions often enriched at the nuclear periphery. Compartmentalization provides fundamental insights into nuclear organization and is tightly coupled with epigenetic states and regulatory activity. In this module, compartment features were identified and analyzed using the PCA algorithm from dcHiC tool.